Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Emerg Infect Dis. 2021 Aug;27(8):2174-2178. doi: 10.3201/eid2708.211145. Epub 2021 Jun 8.


We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

Keywords: B cell; Berlin; COVID-19; Germany; SARS-CoV-2; T cell; antibody; coronavirus disease; immunity; mRNA; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine; viruses; zoonoses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • BNT162 Vaccine
  • COVID-19 Vaccines
  • COVID-19*
  • Germany / epidemiology
  • Humans
  • SARS-CoV-2
  • T-Lymphocytes
  • Vaccination


  • COVID-19 Vaccines
  • BNT162 Vaccine