Development of a risk stratification scoring system for deep vein thrombosis upon psychiatric admission

J Psychosom Res. 2021 Aug;147:110540. doi: 10.1016/j.jpsychores.2021.110540. Epub 2021 May 31.


Aim: Psychiatric patients have increased risk of deep vein thrombosis (DVT). However, there is no systematic data on risk assessment of DVT among psychiatric inpatients. The aim of this study was to develop a risk stratification scoring system for DVT among psychiatic patients on admission.

Methods: A systematic review of psychiatric patient's charts, who were admitted to the Tokyo Metropolitan Matsuzawa Hospital from June 2012 to February 2016 and underwent screening for DVT, was conducted. Patients were randomly divided into development (n = 2634) and validation (n = 2634) groups. Estimated risk values in the multiple logistic regression model for the development sample were rounded to the nearest integer, and used as points of associated factors in the risk stratification scoring system; the total scores were tested in the validation sample. The score's discriminatory ability was assessed with the area under the receiver operating characteristic curve (AUC).

Results: Among the 5268 patients, 258 (4.9%) had DVT. Advancing age, female sex, active cancer, previous venous thromboembolism, transfer from a general hospital, catatonia, and major depressive episode were all significantly associated with the presence of DVT in the development sample. The total score showed good discriminatory ability in the validation sample (AUC: 0.816, 95% confidence interval: 0.781-0.851); scores of 0-1, 2-3, 4-5, and ≥ 6 were associated with very low risk (0.7%), low risk (4.6%), moderate risk (14.9%), and high risk (35%) for DVT, respectively.

Conclusion: Our risk stratification scoring system showed good performance for detection of DVT among psychiatric patients on admission.

Keywords: Deep vein thrombosis; Inpatient; Psychiatric hospital; Pulmonary embolism; Risk score.

Publication types

  • Systematic Review

MeSH terms

  • Depressive Disorder, Major*
  • Female
  • Hospitalization
  • Humans
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Risk Factors
  • Venous Thrombosis*