Regenerative and stem cell-based techniques for facial rejuvenation

Exp Biol Med (Maywood). 2021 Aug;246(16):1829-1837. doi: 10.1177/15353702211020701. Epub 2021 Jun 8.


This review discusses the most novel ideas and modalities being incorporated into facial rejuvenation. Recent innovative techniques include the use of regenerative stem cell techniques and regeneration supportive modalities such as nano-technology or gene therapies. This review aims to investigate approaches that are less well known and lacking established evidence in order to proactively study these techniques prior to them becoming popularized. These applications and relevant research were reviewed in the context of both surgical and non-surgical modalities in clinical practice. Future directions include the concept of "precision cosmetic medicine" utilizing gene editing and cellular therapies to tailor rejuvenation techniques based on each individual's genetic make-up and therefore needs.

Keywords: Stem cells; facial rejuvenation; fat grafting; genetics.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / cytology
  • Cell- and Tissue-Based Therapy* / methods
  • Face / surgery*
  • Humans
  • Regeneration / physiology
  • Rejuvenation / physiology*
  • Stem Cells / cytology*