Evaluation of the Efficacy of Supplementation with Planox® Lemon Verbena Extract in Improving Oxidative Stress and Muscle Damage: A Randomized Double-Blind Controlled Trial

Int J Med Sci. 2021 May 3;18(12):2641-2652. doi: 10.7150/ijms.60726. eCollection 2021.


Excessive exercise load can cause muscle soreness and fatigue, as well as inflammation and oxidative stress. Lemon verbena (Aloysia triphylla; Lippia citriodora) is often used as a spice in tea or beverages. Its leaves are rich in polyphenols, which have antioxidant and anti-inflammatory bioactivities. In the present study, we investigated whether supplementation with Planox® lemon verbena extract (LVE) could improve muscle damage and biochemical indicators after exhaustive exercise challenge. All subjects (30 males and 30 females) underwent a double-blind trial and were randomly divided into a placebo group (0 mg/human/day) and an LVE supplement group (400 mg/human/day), with gender-equal distribution. All subjects started supplementation 10 days before exhaustive exercise and continued it until all tests were completed. Before the intervention, after the exhaustive exercise, and on the following 3 days, the participants underwent 12-minute Cooper running/walking; blood collection; assessments of pain, muscle stiffness, maximum jump heights, and isometric maximum muscle strength. The results showed that supplementation with LVE effectively increased GPx and reduced CK, IL-6, 8-OHdG and muscle pain after the exhaustive exercise, but it had significant effect on strength recovery. In summary, LVE is a safe and edible natural plant extract that can reduce muscle damage and soreness after exercise. This trial was registered at clinicaltrials.gov as NCT04742244.

Keywords: Lemon verbena; inflammation.; muscle injury; oxidative stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Antioxidants / administration & dosage*
  • Antioxidants / adverse effects
  • Dietary Supplements*
  • Double-Blind Method
  • Exercise / adverse effects
  • Female
  • Humans
  • Isometric Contraction / physiology
  • Male
  • Muscle, Skeletal / physiopathology
  • Myalgia / diagnosis
  • Myalgia / diet therapy*
  • Myalgia / etiology
  • Myalgia / physiopathology
  • Oxidative Stress
  • Placebos / administration & dosage
  • Placebos / adverse effects
  • Plant Extracts / administration & dosage*
  • Plant Extracts / adverse effects
  • Verbenaceae / chemistry*
  • Young Adult


  • Antioxidants
  • Placebos
  • Plant Extracts

Supplementary concepts

  • Aloysia

Associated data

  • ClinicalTrials.gov/NCT04742244