LI-RADS treatment response lexicon: review, refresh and resolve with emerging data

Roopa Ram; Rony Kampalath; Anuradha S Shenoy-Bhangle; Sandeep Arora; Ania Z Kielar; Mishal Mendiratta-Lala

doi:10.1007/s00261-021-03149-x

LI-RADS treatment response lexicon: review, refresh and resolve with emerging data

Abdom Radiol (NY). 2021 Aug;46(8):3549-3557. doi: 10.1007/s00261-021-03149-x. Epub 2021 Jun 9.

Authors

Roopa Ram^#¹, Rony Kampalath², Anuradha S Shenoy-Bhangle³, Sandeep Arora⁴, Ania Z Kielar⁵, Mishal Mendiratta-Lala⁶

Affiliations

¹ University of Arkansas for Medical Sciences, 4301 W. Markham St, Little Rock, Ar, 72205, USA. rram@uams.edu.
² Radiological Sciences, University of California, Irvine, 101 The City Drive South, Bldg. 1, Rt. 140, Mail Code: 5005, Orange, CA, 92868, USA.
³ Division of Abdominal Imaging and Interventions, Harvard Medical School, Beth Israel Deaconess Medical Center, Shapiro 4, 330 Brookline Avenue, Boston, MA, 02115, USA.
⁴ Department of Radiology and Biomedical Imaging, Yale University, 333 Cedar Street, New Haven, CT, 06510, USA.
⁵ Dept of Medical Imaging, Toronto General Hospital, University of Toronto, 585 University Ave, Toronto, ON, M5G2N2, Canada.
⁶ Abdominal and Cross-Sectional Interventional Radiology, University of Michigan, 1500 E Medical Center Dr, UH B2 A209R, Ann Arbor, MI48109, USA.

^# Contributed equally.

PMID: 34106301
DOI: 10.1007/s00261-021-03149-x

Abstract

The imaging findings after loco regional treatment of hepatocellular carcinoma are variable based on the type of treatment used, the timing interval of imaging after treatment, and the cross-sectional modality used for treatment response assessment. Liver Imaging Reporting and Data System (LI-RADS) Treatment Response Algorithm (TRA) is a relatively new standardized method of evaluating treatment response after loco regional therapy to hepatocellular carcinoma. In this article, we provide an overview of the evolution of the treatment response algorithm, its current applicability and its outlook for the future. We will review current guidelines and discuss proposed changes to the algorithm as a means to continually improve LI-RADS TRA as an assessment tool post-loco regional treatment of hepatocellular carcinoma.

Keywords: Hepatocellular carcinoma; Radioembolization; Treatment response.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / diagnostic imaging
Carcinoma, Hepatocellular* / therapy
Cross-Sectional Studies
Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / therapy
Magnetic Resonance Imaging
Tomography, X-Ray Computed