Of mitochondrion and COVID-19

J Enzyme Inhib Med Chem. 2021 Dec;36(1):1258-1267. doi: 10.1080/14756366.2021.1937144.


COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment of COVID-19. The current work outlines how COVID-19's signs and symptoms are related to the mitochondrion. Proper understanding of the underlying causes might enhance the opportunity to treat COVID-19.

Keywords: COVID-19; cytokine storm; inflammation; mitochondrion; treatment.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • COVID-19 / metabolism
  • COVID-19 / pathology*
  • COVID-19 Drug Treatment*
  • Humans
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Mitochondria / pathology*
  • SARS-CoV-2 / drug effects
  • SARS-CoV-2 / pathogenicity


  • Antiviral Agents