Reasons why COVID-19 survivors should follow dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations: from hyper-inflammation to cardiac dysfunctions

Eur Rev Med Pharmacol Sci. 2021 May;25(10):3898-3907. doi: 10.26355/eurrev_202105_25957.


The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Recent research indicates that a proper diet could exerts beneficial metabolic and immune effects in humans through the involvement of several, not yet properly known, metabolic pathways. Here, we argue that following WCRF/AICR recommendations could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VTE)] and acute respiratory distress syndrome (ARDS) in patients during follow-up post COVID-19 infection. We discuss the metabolic effects of a WCRF/AICR based diet, highlighting on the involved cardio-metabolic pathways related on NLRP3 inflammasome-cytokines axis aimed to improve prognosis of COVID-19, especially in patients with cancer.

MeSH terms

  • Alcohol Drinking
  • Body Weight
  • COVID-19 / complications
  • COVID-19 / pathology*
  • COVID-19 / virology
  • Carbonated Beverages
  • Cytokines / metabolism
  • Diet*
  • Guidelines as Topic
  • Humans
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neoplasms / complications
  • Neoplasms / pathology*
  • Prognosis
  • Red Meat
  • Risk Factors
  • SARS-CoV-2 / isolation & purification
  • Survivors


  • Cytokines
  • NLR Family, Pyrin Domain-Containing 3 Protein