Initial Failure of Pristinamycin Treatment in a Case of Multidrug-Resistant Mycoplasma genitalium Urethritis Eventually Treated by Sequential Therapy

Romain Palich; Marie Gardette; Cécile Bébéar; Éric Caumes; Sabine Pereyre; Gentiane Monsel

doi:10.1097/OLQ.0000000000001415

Initial Failure of Pristinamycin Treatment in a Case of Multidrug-Resistant Mycoplasma genitalium Urethritis Eventually Treated by Sequential Therapy

Sex Transm Dis. 2021 Nov 1;48(11):e163-e164. doi: 10.1097/OLQ.0000000000001415.

Authors

Romain Palich¹, Marie Gardette², Cécile Bébéar, Éric Caumes¹, Sabine Pereyre, Gentiane Monsel¹

Affiliations

¹ From the Sorbonne University, INSERM, Pierre Louis Epidemiology and Public Health Institute (iPLESP), AP-HP, Pitié-Salpêtrière Hospital, Department of Infectious Diseases, Paris.
² CHU Bordeaux, Bacteriology Department, National Reference Center for Bacterial Sexually Transmitted Infections.

PMID: 34110731
DOI: 10.1097/OLQ.0000000000001415

Abstract

We present a case of persistent Mycoplasma genitalium urethritis with documented macrolide and fluoroquinolone resistance, and we describe the A2062T mutation in the 23S rRNA gene, possibly associated with pristinamycin resistance. After several treatment failures and loss of the A2062T mutation, M. genitalium urethritis was finally cured by a sequential antibiotic treatment including minocycline.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial
Humans
Macrolides
Mycoplasma Infections* / drug therapy
Mycoplasma genitalium* / genetics
Pristinamycin
Urethritis* / drug therapy

Substances

Anti-Bacterial Agents
Macrolides
Pristinamycin