The microbial and host factors that govern Candida gastrointestinal colonization and dissemination

Curr Opin Microbiol. 2021 Oct;63:29-35. doi: 10.1016/j.mib.2021.05.012. Epub 2021 Jun 7.


Candida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of great interest. Here, we review the recent advances and insights regarding Candida colonization and dissemination of the mammalian GI tract.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Candida albicans
  • Candida*
  • Gastrointestinal Tract*
  • Mucous Membrane
  • Symbiosis