Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial

Reprod Biomed Online. 2021 Aug;43(2):246-256. doi: 10.1016/j.rbmo.2021.04.018. Epub 2021 May 7.


Research question: Can participating in a tailored 7-week meditation and mindfulness programme with additional standard supportive care versus standard supportive care only reduce perceived stress for women with recurrent pregnancy loss (RPL)?

Design: A two-armed randomized controlled trial (RCT) with 12-month follow-up. In total 76 patients were enrolled and randomly assigned to either standard supportive care or to a 7-week meditation and mindfulness programme led by an instructor in addition to standard supportive care.

Results: At intervention completion (after 7 weeks), perceived stress decreased significantly both in the intervention group (P = 0.001) and in the control group (P = 0.006). The decrease in perceived stress in the intervention group was significantly larger (P = 0.027) compared with the control group. At the 12-month follow-up perceived stress was still significantly decreased in both groups compared with baseline (P < 0.0001 in the intervention group and P = 0.002 in the control group).

Conclusion: This first RCT of a tailored meditation and mindfulness intervention for women with RPL documents that a 7-week daily at-home meditation and mindfulness programme combined with group sessions reduced perceived stress significantly more than a standard supportive care programme. Future studies should address the most effective format and the 'dose' needed for an impact on perceived stress levels.

Keywords: Education; Meditation; Randomized controlled trial; Recurrent pregnancy loss; Stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Abortion, Habitual / psychology
  • Abortion, Habitual / therapy*
  • Adolescent
  • Adult
  • Denmark
  • Female
  • Follow-Up Studies
  • Humans
  • Meditation* / methods
  • Meditation* / psychology
  • Middle Aged
  • Mindfulness*
  • Perception
  • Pregnancy
  • Stress, Psychological / psychology
  • Stress, Psychological / therapy*
  • Young Adult