Prediction of Successful Memory Encoding Based on Lateral Temporal Cortical Gamma Power

Front Neurosci. 2021 May 25;15:517316. doi: 10.3389/fnins.2021.517316. eCollection 2021.


Prediction of successful memory encoding is important for learning. High-frequency activity (HFA), such as gamma frequency activity (30-150 Hz) of cortical oscillations, is induced during memory tasks and is thought to reflect underlying neuronal processes. Previous studies have demonstrated that medio-temporal electrophysiological characteristics are related to memory formation, but the effects of neocortical neural activity remain underexplored. The main aim of the present study was to evaluate the ability of gamma activity in human electrocorticography (ECoG) signals to differentiate memory processes into remembered and forgotten memories. A support vector machine (SVM) was employed, and ECoG recordings were collected from six subjects during verbal memory recognition task performance. Two-class classification using an SVM was performed to predict subsequently remembered vs. forgotten trials based on individually selected frequencies (low gamma, 30-60 Hz; high gamma, 60-150 Hz) at time points during pre- and during stimulus intervals. The SVM classifier distinguished memory performance between remembered and forgotten trials with a mean maximum accuracy of 87.5% using temporal cortical gamma activity during the 0- to 1-s interval. Our results support the functional relevance of ECoG for memory formation and suggest that lateral temporal cortical HFA may be utilized for memory prediction.

Keywords: electrocorticography; gamma frequency; high-frequency activity; memory formation; memory prediction; successful memory encoding.