Primary structure of neuromedin U from the rat

J Neurochem. 1988 Sep;51(3):988-91. doi: 10.1111/j.1471-4159.1988.tb01837.x.


The primary structure of neuromedin U from the rat ileum was established as: Tyr-Lys-Val-Asn-Glu5-Tyr-Gln-Gly-Pro-Val10-Ala-Pro-Ser-Gly-+ ++Gly15-Phe-Phe-Leu- Phe-Arg20-Pro-Arg-Asn.NH2. There was no evidence for microheterogeneity. This amino acid sequence contains two deletions and nine substitutions compared with the neuromedin U-25 from the pig. In particular, the replacement of the Arg16-Arg17 processing site in the porcine peptide by Gly14-Gly15 in the rat means that a peptide corresponding to neuromedin U-8 was not found in the rat intestine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid
  • Male
  • Molecular Sequence Data
  • Neuropeptides / genetics*
  • Neuropeptides / isolation & purification
  • Rats / metabolism*
  • Rats, Inbred Strains


  • Neuropeptides
  • neuromedin U