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Case Reports
. 2021 Aug;90(2):315-318.
doi: 10.1002/ana.26144. Epub 2021 Jul 2.

Guillain-Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination

Christopher Martin Allen  1   2 , Shelby Ramsamy  1 , Alexander William Tarr  3   4 , Patrick Jason Tighe  3   4 , William Lucien Irving  3   4 , Radu Tanasescu  1   2 , Jonathan Rhys Evans  1
Affiliations
Case Reports

Guillain-Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination

Christopher Martin Allen et al. Ann Neurol. 2021 Aug.

Abstract

Although SARS-CoV-2 vaccines are very safe, we report 4 cases of the bifacial weakness with paresthesias variant of Guillain-Barré syndrome (GBS) occurring within 3 weeks of vaccination with the Oxford-AstraZeneca SARS-CoV-2 vaccine. This rare neurological syndrome has previously been reported in association with SARS-CoV-2 infection itself. Our cases were given either intravenous immunoglobulin, oral steroids, or no treatment. We suggest vigilance for cases of bifacial weakness with paresthesias variant GBS following vaccination for SARS-CoV-2 and that postvaccination surveillance programs ensure robust data capture of this outcome, to assess for causality. ANN NEUROL 2021;90:315-318.

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