Advances in Adoptive Cell Therapy for Head and Neck Cancer

Scott M Norberg; Christian S Hinrichs

doi:10.1016/j.otc.2021.05.001

Advances in Adoptive Cell Therapy for Head and Neck Cancer

Otolaryngol Clin North Am. 2021 Aug;54(4):761-768. doi: 10.1016/j.otc.2021.05.001. Epub 2021 Jun 9.

Authors

Scott M Norberg¹, Christian S Hinrichs²

Affiliations

¹ Genitourinary Malignancy Branch, National Cancer Institute, 10 Center Drive, Room 3-3132, Bethesda, MD 20892, USA. Electronic address: scott.norberg@nih.gov.
² Genitourinary Malignancy Branch, National Cancer Institute, 10 Center Drive, Room 4B04, Bethesda, MD 20892, USA.

PMID: 34116844
DOI: 10.1016/j.otc.2021.05.001

Abstract

This article reviews the most recent literature describing clinical advances in adoptive cell therapy for patients with head and neck cancer. Clinical trials with tumor-infiltrating lymphocyte and gene-engineered T-cell receptor T-cell therapy are highlighted.

Keywords: Adoptive cell therapy; Chimeric antigen receptor; Head and neck cancer; Human papillomavirus; Oropharyngeal squamous cell carcinoma; T-cell receptor; Tumor-infiltrating lymphocyte.

Published by Elsevier Inc.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell*
Cell- and Tissue-Based Therapy
Head and Neck Neoplasms* / therapy
Humans
Lymphocytes, Tumor-Infiltrating
Receptors, Antigen, T-Cell / genetics

Substances

Receptors, Antigen, T-Cell