Acyclovir prevents reactivation of herpes simplex labialis in skiers

JAMA. 1988 Sep 16;260(11):1597-9.

Abstract

To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / therapeutic use*
  • Administration, Oral
  • Adult
  • Colorado
  • Drug Administration Schedule
  • Female
  • Herpes Labialis / prevention & control*
  • Humans
  • Male
  • Random Allocation
  • Recurrence
  • Risk Factors
  • Skiing*
  • Sunlight / adverse effects
  • Sunscreening Agents / therapeutic use
  • Utah

Substances

  • Sunscreening Agents
  • Acyclovir