Heart transplantation from controlled donation after circulatory death using thoracoabdominal normothermic regional perfusion and cold storage

J Card Surg. 2021 Sep;36(9):3421-3424. doi: 10.1111/jocs.15733. Epub 2021 Jun 12.

Abstract

Background: Heart transplantation from controlled donation after the circulatory determination of death (cDCDD) may be an option to increase the pool of grafts for transplantation.

Materials and methods: Initial experiences on cDCDD heart transplantation were based on the direct procurement of the heart followed by preservation with ex situ perfusion devices. Later, the use of thoracoabdominal normothermic regional perfusion (TA-NRP) has emerged as an option to recover hearts. We present a case of a heart transplant using a graft from controlled donation after circulatory death. Cardiac preservation was performed by postmortem TA-NRP followed by cold storage. Ex situ perfusion device was not used.

Discussion and conclusion: This is one of the first published cases of a controlled donation after circulatory death heart retrieved using only TA-NRP and successfully transplanted.

Keywords: donation after circulatory death; extracorporeal membrane oxygenation; transplant.

Publication types

  • Case Reports

MeSH terms

  • Death
  • Heart
  • Heart Transplantation*
  • Humans
  • Organ Preservation
  • Perfusion
  • Tissue Donors
  • Tissue and Organ Procurement*