Emerging biomarkers of delayed graft function in kidney transplantation

Transplant Rev (Orlando). 2021 Dec;35(4):100629. doi: 10.1016/j.trre.2021.100629. Epub 2021 May 26.


Delayed Graft Function (DGF) is one of the most common early complications in kidney transplantation, associated with poor graft outcomes, prolonged post-operative hospitalization and higher rejection rates. Given the severe shortage of high-quality organs for transplantation, DGF incidence is expected to raise in the next years because of the use of nonstandard kidneys from Extended Criteria Donors (ECD) and from Donors after Circulatory Death (DCD). Alongside conventional methods for the evaluation of renal allograft [e.g. serum creatinine Glomerular Filtration Rate (GFR), needle biopsy], recent advancements in omics technologies, including proteomics, metabolomics and transcriptomics, may allow to discover novel biomarkers associated with DGF occurrence, in order to identify early preclinical signs of renal dysfunction and to improve the quality of graft management. Here, we gather contributions from basic scientists and clinical researchers to describe new omics studies in renal transplantation, reporting the emerging biomarkers of DGF that may implement and improve conventional approaches.

Keywords: Biomarkers; DGF; Kidney; Omics; Transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers
  • Delayed Graft Function / epidemiology
  • Delayed Graft Function / etiology
  • Graft Rejection / epidemiology
  • Graft Rejection / etiology
  • Graft Survival
  • Humans
  • Kidney
  • Kidney Transplantation* / adverse effects
  • Risk Factors
  • Tissue Donors


  • Biomarkers