Striatal D-2 dopamine agonist binding sites fluctuate during the rat estrous cycle

Life Sci. 1988;43(8):665-72. doi: 10.1016/0024-3205(88)90137-3.


Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high to low D-2 agonist binding sites from proestrus AM (PAM) to diestrus 1 (D1) and return to OVX value in diestrus 2 (DII). Thus, physiological fluctuations of hormones as occur during the estrous cycle can modulate extrahypothalamic biogenic amine activity, namely striatal DA systems which are not involved in the control of hormone secretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Estradiol / blood
  • Estrus*
  • Female
  • Ovariectomy
  • Progesterone / blood
  • Prolactin / blood
  • Rats
  • Rats, Inbred Strains


  • Progesterone
  • Estradiol
  • Prolactin
  • Dopamine