Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

Front Immunol. 2021 May 28;12:691559. doi: 10.3389/fimmu.2021.691559. eCollection 2021.


Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases.

Keywords: IL-25; IL-25 signal transduction; rheumatoid arthritis; systemic erythematosus lupus; type 2 inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Humans
  • Inflammation / immunology*
  • Interleukin-17 / immunology*
  • Signal Transduction


  • IL25 protein, human
  • Interleukin-17