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. 2021 Aug:15:100282.
doi: 10.1016/j.bbih.2021.100282. Epub 2021 Jun 8.

SARS-CoV-2 RNA detection in cerebrospinal fluid: Presentation of two cases and review of literature

María Belén Luis  1 , Nora Fernández Liguori  1 , Pablo Adrián López  2 , Ricardo Alonso  1
Affiliations

SARS-CoV-2 RNA detection in cerebrospinal fluid: Presentation of two cases and review of literature

María Belén Luis et al. Brain Behav Immun Health. 2021 Aug.

Abstract

Neurological manifestations of SARS-CoV-2 infection are multiple and heterogeneous. However, confirmation of nervous system impairment by viral RNA detection in cerebrospinal fluid (CSF) is uncommon. We report two cases of central nervous system (CNS) involvement with positive real-time reverse-transcriptase polymerase chain reaction (RT-PCR) test in CSF.

Keywords: Encephalitis; Meningoencephalitis; Myelitis; Neuroimaging; SARS-CoV-2; SARS-CoV-2 RNA; SARS-CoV-2 infection; SARS-CoV-2 neurological manifestations.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Case 1 Brain Mri Findings (A - B) Hyperintense lesions on fluid-attenuated inversion-recovery (FLAIR) sequence involving the cerebellum, thalamus and basal ganglia. (C–D) Focal area of markedly increased signal on diffusion-weighted imaging (DWI) with decrease apparent diffusion coefficient (ADC) in the splenium of the corpus callosum.
Fig. 2
Fig. 2
Case 1 Spinal Cord Mri Findings (A-D) Signal hyperintensity on Short Tau Inversion Recovery (STIR) sequence extending from C2 to Th3 level and from Th5 to Th10 (longitudinally extensive myelitis), with patchy and eccentric contrast enhancement. T1 post contrast cervical and lumbar pial enhancement associated to conus medullaris enhancement.
See this image and copyright information in PMC

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