ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis

Zijun Zhao; Yuhao Wu; Zhongxia Zhou; Yan Zhao; Xiaofei Sun; Chan Hu; Xiuli Wang; Guolong Zhang

doi:10.1016/j.pdpdt.2021.102395

ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis

Photodiagnosis Photodyn Ther. 2021 Sep:35:102395. doi: 10.1016/j.pdpdt.2021.102395. Epub 2021 Jun 11.

Authors

Zijun Zhao¹, Yuhao Wu¹, Zhongxia Zhou¹, Yan Zhao¹, Xiaofei Sun¹, Chan Hu¹, Xiuli Wang², Guolong Zhang³

Affiliations

¹ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
² Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: wangxiuli_1400023@tongji.edu.cn.
³ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: glzhangtj@tongji.edu.cn.

PMID: 34126243
DOI: 10.1016/j.pdpdt.2021.102395

Abstract

5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment modality for premalignant and malignant skin lesions. It has the advantage of better tolerance and providing better cosmetic outcomes than conventional treatment methods. Herein, we report a patient who suffered from multiple cutaneous squamous cell carcinoma (cSCC) in situ and actinic keratosis (AK) scattered in the body's sun-exposed areas, which had led him to undergo multiple surgical resections since the age of 16. Next-generation sequencing-based on a targeted gene capture panel revealed compound heterozygous mutations c.G559A and c.G1389A in the TMC8 gene. Combined with the typical clinical manifestations and mutation analysis, the patient was diagnosed with Epidermodysplasia verruciformis (EV). Due to the multiple AK and cSCC in situ lesions, ALA-PDT was applied. After 8 courses of ALA-PDT all lesions were successfully cleared without causing any scarring. Therefore, the use of ALA-PDT treatment may constitute a very promising and effective therapeutic modality for multiple cSCC in situ and AK secondary to EV.

Keywords: ALA-PDT; Actinic keratosis; Cutaneous squamous cell carcinoma; Epidermodysplasia verruciformis; TMC8/EVER2.

Publication types

Case Reports

MeSH terms

Aminolevulinic Acid / therapeutic use
Carcinoma, Squamous Cell* / drug therapy
Epidermodysplasia Verruciformis* / drug therapy
Humans
Keratosis, Actinic* / drug therapy
Male
Membrane Proteins
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
Skin Neoplasms* / drug therapy
Treatment Outcome

Substances

Membrane Proteins
Photosensitizing Agents
TMC8 protein, human
Aminolevulinic Acid