Neuroimaging is the most important tool to treat epileptic foci. Preoperative detection of underlying structural lesions increases the likelihood of the successful surgical treatment of drug-resistant epilepsy. Imaging studies used for preoperative focal determination include morphological imaging modalities, such as computed tomography and magnetic resonance imaging, and functional ones, such as positron emission tomography and single photon-emission computed tomography. The keys to diagnostic imaging in epilepsy are appropriate protocols and extensive knowledge to make comprehensive decisions. This article comprehensively overviews neuroimaging techniques used in epilepsy.