Deconjugative α-Alkylation of Cyclohexenecarboxaldehydes: An Access to Diverse Terpenoids

J Org Chem. 2021 Jul 2;86(13):8742-8754. doi: 10.1021/acs.joc.1c00560. Epub 2021 Jun 15.

Abstract

A general and efficient method for the deconjugative α-alkylation of α,β-unsaturated aldehydes promoted by a synergistic effect between tBuOK and NaH, which considerably increases the reaction rate under mild conditions, is reported. The β,γ-unsaturated aldehyde, resulting from the α-alkylation, is transformed in high yield into the corresponding allyl acetate via a lead(IV) acetate-mediated oxidative fragmentation. This strategy could be used for the construction of the carbon skeleton of a wide variety of alkyl or arylterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes*
  • Alkylation
  • Oxidation-Reduction
  • Stereoisomerism
  • Terpenes*

Substances

  • Aldehydes
  • Terpenes