A Leep1 into migration and macropinocytosis

J Cell Biol. 2021 Jul 5;220(7):e202105141. doi: 10.1083/jcb.202105141. Epub 2021 Jun 15.

Abstract

Actin organization underpins conserved functions at the leading edge of cells. In this issue, Yang et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010096) characterize Leep1 as a bi-functional regulator of migration and macropinocytosis through PIP3 and the Scar/WAVE complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Actins* / genetics
  • Pinocytosis*

Substances

  • Actins