The Effect of Immunobiotic/Psychobiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Narine on Gut Prevotella in Familial Mediterranean Fever: Gender-Associated Effects

Probiotics Antimicrob Proteins. 2021 Oct;13(5):1306-1315. doi: 10.1007/s12602-021-09779-3. Epub 2021 Jun 16.


Possible mechanisms involved in sex-dependent differences in the gut microbiota have a growing interest worldwide, but the effects of probiotics dependence on the gender of the host have remained outside of researchers' attention until now. Previously, our research data described gender-specific differences in the gut microbiota of Armenian Familial Mediterranean fever (FMF) patients. Taking into account the possible association of Prevotella spp. with depressive disorders, the aim of the current investigations was an evaluation of changes in the abundance of gut Prevotella of FMF patients in association with the patient's depression and gender. The differences between healthy and FMF diseased gut microbiota in terms of Prevotella abundance were revealed. In addition, the gender-dependent effects of immunobiotic/psychobiotic Narine on the abundance of gut Prevotella of FMF patients and patients' depression scores were shown by us in this study.

Keywords: Depression level; Familial Mediterranean fever; Gut microbiota; Immunobiotic Narine; Patients’ gender; Prevotella; Psychobiotic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Depression
  • Familial Mediterranean Fever* / therapy
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Lactobacillus acidophilus*
  • Male
  • Prevotella*
  • Probiotics*
  • Sex Factors*