What a difference ADA2 makes: Insights into the pathophysiology of ADA2 deficiency from single-cell RNA sequencing of monocytes

J Leukoc Biol. 2021 Sep;110(3):405-407. doi: 10.1002/JLB.5CE0421-186R. Epub 2021 Jun 16.


Discussion on the increase in nonclassical monocytes in patients with DADA2 as shown by scRNA seq; these pro inflammatory cells also show increased TNFR2, type I, and type II IFN pathway gene expression.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine Deaminase* / genetics
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Monocytes*
  • Mutation
  • Sequence Analysis, RNA


  • Intercellular Signaling Peptides and Proteins
  • Adenosine Deaminase