Where ketamine and dopamine collide

David J Marcus; Michael R Bruchas

doi:10.7554/eLife.70148

Where ketamine and dopamine collide

Elife. 2021 Jun 17:10:e70148. doi: 10.7554/eLife.70148.

Authors

David J Marcus¹, Michael R Bruchas²

Affiliations

¹ Department of Anesthesiology and Pain Medicine and Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States.
² Department of Anesthesiology and Pain Medicine, Center for Neurobiology of Addiction, Pain, and Emotion, and Department of Pharmacology, University of Washington, Seattle, United States.

Abstract

Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.

Keywords: VTA; antidepressants; aversive learning; dopamine; ketamine; mPFC; mouse; neuroscience.

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MeSH terms

Dopamine
Ketamine*
Prefrontal Cortex

Substances

Ketamine
Dopamine