Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

J Agric Food Chem. 2021 Jun 30;69(25):7000-7015. doi: 10.1021/acs.jafc.1c01465. Epub 2021 Jun 17.


High intake of dietary fibers was found to be inversely associated with type-2 diabetes (T2D), whereas the difference among different dietary fibers on T2D remains unclear. Therefore, we have investigated the effects of different dietary fibers on T2D. Nine types of dietary fibers were used to investigate and evaluate their effects on type-2 diabetic rats via physiology, genomics, and metabolomics. We found that supplementation with β-glucan, arabinogalactan, guar gum, apple pectin, glucomannan, and arabinoxylan significantly reduced the fasting blood glucose, whereas carrageenan, xylan, and xanthan gum did not affect glycemic control in diabetic rats. Also, bioactive dietary fibers (β-glucan, arabinogalactan, guar gum, and apple pectin) associated with the increased butyric acid level and abundance of beneficial bacteria (Lachnobacterium, Parabacteroides, Faecalibacterium, Akkermansia, and some butyric acid-producing bacteria), as well as improved host metabolism by decreasing 12α-hydroxylated bile acids, acylcarnitines, and amino acids (leucine, phenylalanine, citrulline, etc.), thereby exert beneficial effects on T2D. It was also found that β-glucan might attenuate insulin resistance via downregulation of Prevotella copri-mediated biosynthesis of branched-chain amino acids in T2D. Together, our study uncovered the effects of different dietary fibers on T2D, along with their potential mechanism.

Keywords: dietary fiber; gut microbiota; metabolomics; multiomics analysis; type-2 diabetes.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental* / drug therapy
  • Dietary Fiber
  • Gastrointestinal Microbiome*
  • Hypoglycemic Agents
  • Prevotella
  • Rats


  • Dietary Fiber
  • Hypoglycemic Agents

Supplementary concepts

  • Prevotella copri