Objective: To investigate the association between shift work and the risk of lower extremity osteoarthritis. Methods: The study population came from the Dongfeng-Tongji cohort established in 2008. In September 2008, the Dongfeng Motor Company in Hubei Province was to recruit all retired workers who voluntarily participated in the survey as the research objects. During the follow-up conducted from April to October 2013, a total of 14 438 retired workers, i.e. all of the participants who underwent physical examination were investigated about demographic characteristics, lifestyles, occupation history, and lower extremity joint-related medical history, and additionally completed lower extremity joint examinations. After excluding individuals with missing data regarding lower extremity osteoarthritis, with the history of lower extremity joint trauma, or with history of rheumatoid arthritis (N=532), data from 13 906 participants was analyzed in the study. Multivariate logistic regression models were used to estimate the association between shift work and lower extremity osteoarthritis. After stratified by the duration of shift work, multivariate logistic regression models were used to analyze the relationship between the duration after leaving from shift work and lower extremity osteoarthritis. Results: Finally, a total of 13 906 retired employees included 7 560 (54.4%) females with a mean age of 64.74 (standard deviation 8.23) years old. 5 537 (39.8%) workers had ever engaged in shift work, including 2 004 (14.4%) workers with 1-9 years of shift work and 3 533 (25.4%) workers with ≥ 10 years of shift work. The prevalence of lower extremity osteoarthritis was 7.0%, while the prevalence of knee osteoarthritis and hip osteoarthritis were 6.7% and 0.7%, respectively. Compared with daytime workers, shift workers showed a 22% increase in the risk of lower extremity osteoarthritis (OR=1.22, 95%CI:1.06-1.40). Each 5-year increase in the duration of shift work was associated with a 4% increase in the risk of lower extremity osteoarthritis (OR=1.04, 95%CI:1.01-1.08). With the extension of the duration after leaving from shift work, the risk of lower extremity osteoarthritis decreased. Similar relationships were found between shift work and the risk of knee osteoarthritis, as well as hip osteoarthritis. Conclusion: Shift work was associated with the increased risk of lower extremity osteoarthritis.
目的： 探讨轮班作业与下肢骨性关节炎患病风险的关联。 方法： 研究对象来源于2008年建立的东风-同济队列。于2008年9月，以湖北省的东风汽车公司作为研究现场，招募自愿参加调查的所有退休工人为研究对象，并于2013年4—10月进行第一次随访。本研究对14 438名接受健康体检的对象进行人口学特征、生活方式、职业史和下肢关节相关病史的问卷调查以及下肢关节体格检查。排除下肢骨性关节炎信息缺失者、下肢关节外伤史者、类风湿关节炎患者（532名）后，最终共纳入13 906名研究对象。采用多因素logistic回归模型分析轮班作业与下肢骨性关节炎的关联性。按轮班作业时长分层后，采用多因素logistic回归模型分析离开轮班岗位时长与下肢骨性关节炎的关联性。 结果： 13 906名研究对象年龄为（64.74±8.23）岁，其中女性7 560名（占54.4%）。从事轮班作业的工人共有5 537名（占39.8%），包括轮班作业时长1~9年者2 004名（占14.4%）和≥10年者3 533名（占25.4%）。研究对象下肢骨性关节炎的患病率为7.0%，其中膝、髋骨性关节炎患病率分别为6.7%和0.7%。结果显示，轮班作业工人较白班工人的下肢骨性关节炎患病风险增加22%（OR=1.22，95%CI：1.06~1.40）。轮班作业时长每增加5年，下肢骨性关节炎的患病风险增加4%（OR=1.04，95%CI：1.01~1.08）。随着离开轮班岗位时长增加，下肢骨性关节炎的患病风险下降。轮班作业与膝、髋骨性关节炎患病风险也有类似的关联。 结论： 轮班作业与退休工人下肢骨性关节炎患病风险有关联。.