The Role of Growth Hormone in Chronic Kidney Disease

Semin Nephrol. 2021 Mar;41(2):144-155. doi: 10.1016/j.semnephrol.2021.03.009.


Growth hormone (GH) has become a critical therapy for treating growth delay and failure in pediatric chronic kidney disease. Recombinant human GH treatment is safe and significantly improves height and height velocity in these growing patients and improved growth outcomes are associated with decreased morbidity and mortality as well as improved quality of life. However, the utility of recombinant human GH in adults with chronic kidney disease and end-stage renal disease for optimization of body habitus and reducing frailty remains uncertain. Semin Nephrol 41:x-xx © 2021 Elsevier Inc. All rights reserved.

Keywords: Growth hormone; cachexia; chronic kidney disease; growth failure; quality of life; short stature.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Body Height
  • Child
  • Growth Hormone / therapeutic use
  • Human Growth Hormone* / therapeutic use
  • Humans
  • Quality of Life
  • Renal Insufficiency, Chronic* / drug therapy


  • Human Growth Hormone
  • Growth Hormone