Radiotherapy and Immunotherapy Combinations in the Treatment of Patients with Metastatic Disease: Current Status and Future Focus

William Tyler Turchan; Sean P Pitroda; Ralph R Weichselbaum

doi:10.1158/1078-0432.CCR-21-0145

Radiotherapy and Immunotherapy Combinations in the Treatment of Patients with Metastatic Disease: Current Status and Future Focus

Clin Cancer Res. 2021 Oct 1;27(19):5188-5194. doi: 10.1158/1078-0432.CCR-21-0145.

Authors

William Tyler Turchan¹, Sean P Pitroda¹, Ralph R Weichselbaum¹

Affiliation

¹ University of Chicago, Department of Radiation and Cellular Oncology, Chicago, Illinois.

PMID: 34140404
DOI: 10.1158/1078-0432.CCR-21-0145

Abstract

Radiotherapy and immunotherapy benefit subsets of patients with metastatic cancer. Here, we review selected laboratory and clinical studies investigating the utility of combining radiotherapy and immunotherapy in metastatic patients. We examine potential approaches to increase the therapeutic ratio of radioimmunotherapy in the treatment of metastatic cancers moving forward.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Combined Modality Therapy
Humans
Immunotherapy / adverse effects
Neoplasms* / pathology
Neoplasms, Second Primary* / etiology
Radioimmunotherapy