Favorable long-term outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumor

J Gastroenterol Hepatol. 2021 Dec;36(12):3329-3336. doi: 10.1111/jgh.15586. Epub 2021 Jun 23.


Background and aim: The long-term outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumors are limited. We aimed to clarify it.

Methods: Consecutive patients with nonampullary duodenal neuroendocrine tumors endoscopically treated at our institute between January 2005 and June 2020 were included in this retrospective study. En bloc and R0 resection rates and adverse events were evaluated as short-term outcomes of endoscopic resection. The 5-year overall and recurrence-free survival rates of patients after endoscopic resection were calculated as long-term outcomes.

Results: Of 34 patients with 34 lesions, 33 patients (97%) underwent endoscopic mucosal resection, and one (3%) underwent endoscopic submucosal dissection. En bloc resection was achieved in 33 lesions (97%). R0 resection was achieved in 20 lesions (59%). The median tumor size was 6 mm (range: 3-13). Thirty-one lesions (91%) and three lesions (9%) were classified as G1 and G2, respectively. Lymphovascular invasion was observed in six lesions (18%). Intraprocedural perforation occurred in four patients (12%) who were conservatively treated with endoscopic closure. All 34 patients were followed up without additional treatment after endoscopic resection, and no recurrence or metastasis developed during the median follow-up period of 47.9 months (range: 9.0-187.1). The 5-year overall survival and recurrence-free survival rates were 87.1% and 100%, respectively.

Conclusions: Endoscopic resection provided a favorable long-term prognosis for patients with nonampullary duodenal neuroendocrine tumors without lymph node metastasis.

Keywords: duodenum; endoscopic mucosal resection; neuroendocrine tumors.

MeSH terms

  • Aged
  • Duodenal Neoplasms* / diagnostic imaging
  • Duodenal Neoplasms* / pathology
  • Duodenal Neoplasms* / surgery
  • Endoscopic Mucosal Resection*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Neoplasm Staging
  • Neuroendocrine Tumors* / diagnostic imaging
  • Neuroendocrine Tumors* / pathology
  • Neuroendocrine Tumors* / surgery
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome