Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021

Euro Surveill. 2021 Jun;26(24):2100452. doi: 10.2807/1560-7917.ES.2021.26.24.2100452.


Residents in long-term care facilities (LTCF) experienced a large morbidity and mortality during the COVID-19 pandemic in Spain and were prioritised for early COVID-19 vaccination. We used the screening method and population-based data sources to obtain estimates of mRNA COVID-19 vaccine effectiveness for elderly LTCF residents. The estimates were 71% (95% CI: 56-82%), 88% (95% CI: 75-95%), and 97% (95% CI: 92-99%), against SARS-CoV-2 infections (symptomatic and asymptomatic), and COVID-19 hospitalisations and deaths, respectively.

Keywords: COVID-19; LTCF; screening; surveillance; vaccination.

MeSH terms

  • Aged
  • COVID-19 Vaccines*
  • COVID-19*
  • Hospitalization
  • Humans
  • Long-Term Care
  • Pandemics
  • RNA, Messenger
  • SARS-CoV-2
  • Spain / epidemiology


  • COVID-19 Vaccines
  • RNA, Messenger