Growth in children on kidney replacement therapy: a review of data from patient registries

Pediatr Nephrol. 2021 Aug;36(8):2563-2574. doi: 10.1007/s00467-021-05099-4. Epub 2021 Jun 18.

Abstract

Growth retardation is a major complication in children with chronic kidney disease (CKD) and on kidney replacement therapy (KRT). Conversely, better growth in childhood CKD is associated with an improvement in several hard morbidity-mortality endpoints. Data from pediatric international registries has demonstrated that improvements in the overall conservative management of CKD, the search for optimal dialysis, and advances in immunosuppression and kidney transplant techniques have led to a significant improvement of final height over time. Infancy still remains a critical period for adequate linear growth, and the loss of stature during the first years of life influences final height. Preliminary new original data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry confirm an association between the final height and the height attained at 2 years in children on KRT.

Keywords: Children; Chronic kidney disease; Dialysis; Final height; Growth; Kidney replacement therapy; Transplant.