Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital

Hypertens Pregnancy. 2021 Aug;40(3):202-208. doi: 10.1080/10641955.2021.1939712. Epub 2021 Jun 18.

Abstract

Background: This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT).Method: 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated.Results: NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04).Conclusion: NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.

Keywords: NT-proBNP; chronic hypertension; perinatal outcome; pregnancy.

MeSH terms

  • Biomarkers / blood
  • Case-Control Studies
  • Female
  • Humans
  • Hypertension / complications*
  • Hypertension / epidemiology
  • Infant, Low Birth Weight* / blood
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Pregnancy
  • Pregnancy Trimester, First
  • Prognosis
  • Prospective Studies
  • Tertiary Care Centers

Substances

  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain