Analysis of endogenous oxidative damage markers and association with pulmonary involvement severity in patients with SARS-CoV-2 pneumonia

Infect Dis Now. 2021 Aug;51(5):429-434. doi: 10.1016/j.idnow.2021.06.302. Epub 2021 Jun 17.


Introduction: The SARS-CoV-2 virus affects many organs, especially the lungs, with widespread inflammation. We aimed to compare the endogenous oxidative damage markers of coenzyme Q10, nicotinamide dinucleotide oxidase 4, malondialdehyde, and ischemia-modified albumin levels in patients with pneumonia caused by SARS-CoV-2 and in an healthy control group. We also aimed to compare these parameters between patients with severe and non-severe pulmonary involvement.

Methods: The study included 58 adult patients with SARS-CoV-2 pneumonia and 30 healthy volunteers. CoQ10 and MDA levels were determined by high-pressure liquid chromatography. NOX4 and IMA levels were determined by ELISA assay and colorimetric method.

Results: Higher levels of CoQ10, MDA, NOX4, and IMA and lower levels of COQ10H were observed in patients with SARS-CoV-2 pneumonia than in the control group. MDA, IMA, NOX4, and CoQ10 levels were significantly higher in patients with severe pulmonary involvement than in patients with non-severe pulmonary involvement, but no significant difference was observed in CoQ10H levels. CoQ10 levels were significantly and positively correlated with both ferritin and CRP levels.

Conclusion: SARS-CoV-2 pneumonia is significantly associated with increased endogenous oxidative damage. Oxidative damage seems to be associated with pulmonary involvement severity.

Keywords: COVID-19; CoQ10; NOX4; Oxidative damage; Pneumonia; SARS-CoV-2.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • COVID-19 / blood*
  • COVID-19 / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / metabolism*
  • Severity of Illness Index


  • Biomarkers