Alternative polyadenylation-associated loci interpret human traits and diseases

Zhixiao Fang; Shengli Li

doi:10.1016/j.tig.2021.06.002

Alternative polyadenylation-associated loci interpret human traits and diseases

Trends Genet. 2021 Sep;37(9):773-775. doi: 10.1016/j.tig.2021.06.002. Epub 2021 Jun 17.

Authors

Zhixiao Fang¹, Shengli Li²

Affiliations

¹ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: shengli.li@shsmu.edu.cn.

PMID: 34148698
DOI: 10.1016/j.tig.2021.06.002

Abstract

Alternative polyadenylation (APA)-associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.

Keywords: alternative polyadenylation; complex traits; human diseases; quantitative trait loci.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

3' Untranslated Regions
Humans
Multifactorial Inheritance
Phenotype
Polyadenylation*
Quantitative Trait Loci*

Substances

3' Untranslated Regions