Clinical Characteristics of Critically Ill Patients Infected with COVID-19 in Rasoul Akram Hospital in Iran: A Single Center Study

Poupak Rahimzadeh; Saied Amniati; Reza Farahmandrad; Seyed Hamid Reza Faiz; Setareh Hedayati Emami; Azadeh Habibi

doi:10.5812/aapm.107211

Clinical Characteristics of Critically Ill Patients Infected with COVID-19 in Rasoul Akram Hospital in Iran: A Single Center Study

Anesth Pain Med. 2020 Sep 16;10(5):e107211. doi: 10.5812/aapm.107211. eCollection 2020 Oct.

Authors

Poupak Rahimzadeh¹, Saied Amniati², Reza Farahmandrad², Seyed Hamid Reza Faiz², Setareh Hedayati Emami³, Azadeh Habibi³

Affiliations

¹ Pain Research Center, Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran.
² Rasoul Akram Hospital Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran.
³ Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Knowledge about clinical features of critically ill patients with COVID-19 still lacks adequate information up to now.

Objectives: We aimed to describe and compare the epidemiological and clinical characteristics of critically ill patients with COVID-19 in Rasoul Akram Hospital.

Methods: In this case series, 70 critically ill patients with COVID-19 admitted in ICU wards of Rasoul Akram Hospital, Tehran, Iran, from 29 February to 25 April 2020 were enrolled. Demographic and clinical characteristics, laboratory data, and outcomes of the patients were all collected and compared between deceased and recovered patients.

Results: Fifty-six cases had died of COVID-19, and 14 patients had fully recovered and discharged. The median age of the patients was 68 years old, ranging from 22 to 91 years, 66% were men, 80% had one or more comorbidities, and hypertension was the most common comorbidities (45% of deceased cases). The most common signs and symptoms at the onset of illness were SPO₂ depression (92%) and dyspnea (90%). Dyspnea was significantly more common in deceased patients (95%) than recovered patients (70%) (P = 0.048). Most patients had lymphopenia (80%). The number of patients who needed mechanical ventilation in the deceased patients was 53 (95%), which was significantly more than the recovered patients (10 [70%]) (P = 0.048).

Conclusions: The mortality rate of critically ill patients with COVID-19 is very high, and the patients with dyspnea and required mechanical ventilation are at higher risk for death.

Keywords: COVID-19; Critically Ill; ICU; Mortality; Pandemic.