Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis

Debasmita Mukhopadhyay; Nour AlSawaftah; Ghaleb A Husseini

doi:10.1021/acsptsci.1c00040

Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis

ACS Pharmacol Transl Sci. 2021 Apr 16;4(3):1075-1078. doi: 10.1021/acsptsci.1c00040. eCollection 2021 Jun 11.

Authors

Debasmita Mukhopadhyay¹, Nour AlSawaftah¹, Ghaleb A Husseini¹

Affiliation

¹ Chemical Engineering Department, American University of Sharjah, Sharjah, United Arab Emirates.

Abstract

In this study, we investigated the interactions between SARS-CoV-2 and miRNAs associated with lung cancer using bioinformatic approaches. A special focus was placed on TMPRSS2 and lung cancer progression pathways involving AKT/PI3K/PTEN genes.