Neurological basis of respiratory complications in achondroplasia

Ann Neurol. 1988 Jul;24(1):89-93. doi: 10.1002/ana.410240117.


Evaluation of 32 individuals with achondroplasia revealed that 28% had a history of apnea and 22% had respiratory abnormalities on polysomnography. In those patients requiring posterior fossa decompressive surgery, improvement was noted in follow-up polysomnograms. Multimodality studies suggested that brainstem compression was common in achondroplasia and could account in part for the abnormal respiratory function in this disorder, including obstructive apnea, central apnea, and hypoxemia.

MeSH terms

  • Achondroplasia / physiopathology*
  • Adolescent
  • Adult
  • Brain Stem / physiopathology*
  • Child
  • Child, Preschool
  • Evoked Potentials, Somatosensory
  • Female
  • Humans
  • Infant
  • Male
  • Monitoring, Physiologic
  • Nerve Compression Syndromes / physiopathology
  • Respiratory Insufficiency / physiopathology*
  • Sleep Apnea Syndromes / physiopathology
  • Sleep, REM / physiology