Targeted therapy of non-small cell lung cancer

Abstract

The review article presents the current state and development of the treatment with tyrosine kinase inhibitors in advanced non-small cell lung cancer. It focuses on the therapeutic progress of traditionally targeted gene mutations EGFR, ALK and ROS1, as well as new established or promising targets. Mutations in the BRAF, NTRK, RET, cMET, HER2 and KRAS genes are discussed in this regard. In EGFR mutations, it focuses mainly on possible combination therapy and treatment for mutations in exon 20. In ALK translocation, it points to a new generation of tyrosine kinase inhibitors. In ROS1, the article mentions possible treatment in addition to the usual krizotinib, including the treatment after disease progression. For other genes, the author lists newly approved molecules, or molecules in the promising phase of their development.

Keywords: Non-small cell lung cancer; Tyrosine kinase inhibitors; targeted therapy; tyrosine kinase inhibitors.