Pathways of metabolic rehabilitation of cancer patients are discussed. The effectiveness of a long-term carbohydrate, fat and cholesterol restricted diet and hypolipidemic and antidiabetic medication for breast, gastric and colorectal cancers was demonstrated for the first time. The results of gastro-intestinal cancer treatment were especially encouraging. Metabolic rehabilitation chiefly resulted in a lower frequency of metastatic spread. Also, its effect was seen in a rarer primary multiple tumor development. The results make a case for further development of investigations in normalizing fat-carbohydrate metabolism as adjuvant therapy for cancer in postoperative period.