Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review

Bioorg Chem. 2021 Sep:114:105076. doi: 10.1016/j.bioorg.2021.105076. Epub 2021 Jun 10.

Abstract

N-heterocycles are important, not only because of their abundance, but above all because of their chemical, biological and technical significance. They play an important role in biological investigation such as anticancer, antiinflammatory, antibacterial, antiviral, anti-tumor, antidiabetic, etc. In this study, we focused on examining synthesized some 5- or 6-ring N-heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of these compounds structure-activity relationship studies. This review will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

Keywords: Antiviral activity; N-heterocyclic compound; Structure-activity relationship.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Nitrogen / chemistry
  • Nitrogen / pharmacology*
  • Viruses / drug effects*

Substances

  • Antiviral Agents
  • Heterocyclic Compounds
  • Nitrogen