The one-and-a-half syndrome. Clinical correlation with a pontine lesion demonstrated by nuclear magnetic resonance imaging in a case of multiple sclerosis

Br J Ophthalmol. 1988 Jul;72(7):515-7. doi: 10.1136/bjo.72.7.515.


Nuclear magnetic resonance (NMR) imaging has been used to visualise a localised area of demyelination in the dorsal pons of a patient who presented with an unusual disorder of eye movements, namely, the one-and-a-half syndrome. Judged clinically the patient made a nearly complete recovery, but little change was apparent in the NMR image six months later.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Diseases / complications
  • Brain Diseases / diagnosis
  • Brain Diseases / pathology
  • Demyelinating Diseases / diagnosis
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / complications*
  • Ophthalmoplegia / etiology*
  • Pons / pathology*
  • Syndrome