Revisiting CCL-type chemokines in breast cancer and its milieu: prominent targetable chemokines, CCL8 and CCL21

Biosci Rep. 2021 Jul 30;41(7):BSR20210033. doi: 10.1042/BSR20210033.

Abstract

The patterns of chemokine expression play a decisive role in both breast cancer prognosis and metastasis. In a recent article published in Bioscience Reports, 'Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment', Chen et al. presented that expression of both CCL8 and CCL21 among CCL-type chemokines is prominent for prognosis of the breast cancer, metastasis and chemoresistance (Biosci Rep (2020) 40(11); DOI: 10.1042/BSR20202042). Identifying the sources of the CCL8 and CCL21 in the tumor microenvironment and developing targeting strategies for these chemokines to prevent tumor growth will improve both prognosis and therapeutic outcomes.

Keywords: bioinformatics; biomarkers; breast cancers; chemokines; immunology; transcriptomics.

Publication types

  • Comment

MeSH terms

  • Breast Neoplasms* / drug therapy
  • Breast Neoplasms* / genetics
  • Chemokine CCL21 / genetics
  • Chemokine CCL8
  • Chemokines
  • Computational Biology
  • Female
  • Humans
  • Tumor Microenvironment

Substances

  • CCL21 protein, human
  • CCL8 protein, human
  • Chemokine CCL21
  • Chemokine CCL8
  • Chemokines