SARS-CoV-2 Variants and Vaccines

N Engl J Med. 2021 Jul 8;385(2):179-186. doi: 10.1056/NEJMsr2105280. Epub 2021 Jun 23.


Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have increased transmissibility or virulence, the importance of efficient public health measures and vaccination programs will increase. The global response must be both timely and science based.

MeSH terms

  • COVID-19 / prevention & control*
  • COVID-19 / transmission
  • COVID-19 Vaccines* / immunology
  • Humans
  • Immunogenicity, Vaccine
  • Mutation
  • SARS-CoV-2* / pathogenicity
  • Spike Glycoprotein, Coronavirus / genetics
  • Virulence


  • COVID-19 Vaccines
  • Spike Glycoprotein, Coronavirus