Expressed recombinant cadherins mediate cell sorting in model systems

Cell. 1988 Sep 23;54(7):993-1001. doi: 10.1016/0092-8674(88)90114-6.


Cadherins are cell-surface glycoproteins responsible for Ca2+-dependent cell-to-cell adhesion. E- or P-cadherin was transfected into L cells, which normally have little cadherin activity, and cellular aggregation of the resulting transfectants was observed to be a function of the cadherin molecule expressed. Transfected cells preferentially adhered to cells expressing the same cadherin subclass. Furthermore, in reconstituted embryonic lung tissue, E-cadherin-expressing L cells were associated with epithelial tubules expressing E-cadherin, while untransfected L cells associated with mesenchymal cells. These results provide the first direct evidence that the differential expression of cadherins can play a role in cell sorting in heterogeneous cell populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agglutination
  • Animals
  • Antigens, Surface / genetics
  • Antigens, Surface / physiology*
  • Cell Adhesion Molecules
  • Cell Adhesion*
  • Cell Aggregation
  • Genetic Vectors
  • L Cells
  • Lung / cytology
  • Lung / embryology
  • Mice
  • Mice, Inbred ICR
  • Models, Genetic
  • Protein Binding
  • Recombinant Proteins / pharmacology
  • Time Factors
  • Transfection


  • Antigens, Surface
  • Cell Adhesion Molecules
  • Recombinant Proteins