Effect of melatonin on intraocular pressure

Curr Eye Res. 1988 Jul;7(7):649-53. doi: 10.3109/02713688809033192.


We studied the effect of orally administered melatonin on intraocular pressure in humans. We suppressed serum melatonin levels by exposing our subjects to bright light. Our experiments suggest that melatonin lowers intraocular pressure in man. This may prove to be a therapeutically useful agent since melatonin appears to be relatively free of side effects and is effective in small quantities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Circadian Rhythm
  • Humans
  • Intraocular Pressure / drug effects*
  • Intraocular Pressure / radiation effects
  • Light*
  • Melatonin / analogs & derivatives
  • Melatonin / antagonists & inhibitors
  • Melatonin / pharmacology*
  • Melatonin / urine


  • Melatonin
  • 6-hydroxymelatonin