COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center

Epilepsy Behav. 2021 Sep:122:108160. doi: 10.1016/j.yebeh.2021.108160. Epub 2021 Jun 21.


Introduction: Due to the high demand for information regarding COVID-19 vaccination in people with epilepsy (PWE), we assessed the symptoms and seizure control of PWE following their COVID-19 vaccination.

Methods: All adult patients who were treated at our center were asked to report on their vaccination status and, if vaccinated, about their experiences following their first COVID-19 vaccination with regard to adverse effects and seizure control.

Results: Fifty-four PWE have already received their first vaccination against COVID-19 (27 female, 20% seizure free, 96<% on antiseizure medication) and were included in the study. Two-thirds tolerated the vaccines generally either very well or well. Thirty-three percent reported general vaccination adverse effects. The most frequently reported general adverse effects were, in descending order, headache, fatigue and fever, and shivering. With regard to epilepsy-related adverse effects, one patient reported increased seizure frequency one day after the first COVID-19 vaccination was administered, and one reported the occurrence of a new seizure type. None of the patients reported a status epilepticus or aggravation of preexisting adverse effects.

Conclusions: Our data suggest that vaccination against COVID-19 appears to be well tolerated in PWE, supporting the recommendation of vaccination to PWE.

Keywords: Adverse effect; COVID-19 pandemic; Epilepsy; SARS-CoV-2; Vaccination.

MeSH terms

  • Adult
  • COVID-19 Vaccines
  • COVID-19*
  • Epilepsy*
  • Female
  • Humans
  • SARS-CoV-2
  • Vaccination


  • COVID-19 Vaccines