Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota

Renuka R Nayak

doi:10.1016/j.jid.2021.01.003

Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota

J Invest Dermatol. 2021 Jul;141(7):1630-1632. doi: 10.1016/j.jid.2021.01.003.

Author

Renuka R Nayak¹

Affiliation

¹ Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA. Electronic address: Renuka.Nayak@ucsf.edu.

PMID: 34167722
DOI: 10.1016/j.jid.2021.01.003

Abstract

Shi et al. (2021) in "Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice" show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.

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MeSH terms

Animals
Diet, Western / adverse effects
Gastrointestinal Microbiome*
Joint Diseases*
Mice
Psoriasis* / etiology
Skin